Derma fillers are natural or synthetic materials tha tre injected into the skin to create a firmer, more youthful appearance. As we age, our skin gradually loses collagen and fat, producing lines, wrinkles and sagginess in the epidermis. Derma fillers help plump the skin, making it look fuller and healthier. Collagen and other filler, including Juvederm and Restylane, have been used for years in lip enhancement, lip augmentation, wrinkle correction and other skin rejuvenation procedures.